Iminosugar-based glycopolypeptides: glycosidase inhibition with bioinspired glycoprotein analogue micellar self-assemblies

被引：76

作者：

Bonduelle, Colin ^{[1
,2
]}

Huang, Jin ^{[3
]}

Mena-Barragan, Teresa ^{[4
]}

Ortiz Mellet, Carmen ^{[4
]}

Decroocq, Camille ^{[5
,6
]}

Etame, Emile ^{[5
,6
]}

Heise, Andreas ^{[3
]}

Compain, Philippe ^{[5
,6
,7
]}

Lecommandoux, Sebastien ^{[1
,2
]}

机构：

[1] Univ Bordeaux, IPB, ENSCBP, F-33607 Pessac, France

[2] CNRS, Lab Chim Polymeres Organ, UMR5629, Pessac, France

[3] Dublin City Univ, Sch Chem Sci, Dublin 9, Ireland

[4] Univ Seville, Fac Chem, Dept Organ Chem, Seville 41012, Spain

[5] Univ Strasbourg, Lab Synth Orgn & Mol Bioact, F-67087 Strasbourg, France

[6] CNRS, UMR 7509, Ecole Europeenne Chim Polymeres & Mat, F-67087 Strasbourg, France

[7] Inst Univ France, F-75005 Paris, France

来源：

CHEMICAL COMMUNICATIONS | 2014年 / 50卷 / 25期

基金：

爱尔兰科学基金会;

关键词：

RING-OPENING POLYMERIZATION; CLICK CLUSTERS; MULTIVALENT; FUNCTIONALIZATION; GLYCOPOLYMERS; GLYCOPEPTIDES; GLYCOBIOLOGY; POLYPEPTIDES; LECTINS; BINDING;

D O I：

10.1039/c3cc48190e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Biomimetic nanoparticles prepared by self-assembly of iminosugar-based glycopolypeptides evidenced remarkablemultivalency properties when inhibiting alpha-mannosidase activity. This approach paves the way to obtain biologically active drug delivery systems having glycosidase inhibition potency.

引用

收藏

页码：3350 / 3352

页数：3

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