Increased microbicidal activity of green tea (Camellia sinensis) in combination with butylated hydroxyanisole

被引：16

作者：

Simonetti, G

Simonetti, N

Villa, A

机构：

[1] Univ Roma La Sapienza, Dipartimento Med Sperimentale & Patol, I-00185 Rome, Italy

[2] Univ Roma La Sapienza, Inst Microbiol, Fac Pharm, Rome, Italy

来源：

JOURNAL OF CHEMOTHERAPY | 2004年 / 16卷 / 02期

关键词：

microbicidal activity; Camellia sinensis; green tea; Streptococcus mutans; E; coli; C; albicans;

D O I：

10.1179/joc.2004.16.2.122

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We have demonstrated that green tea (Camellia sinensis) shows increased antimicrobial activity against bacteria and fungi when used in combination with butylated hydroxyanisole (BHA). Glycolic extract taken from green tea showed only limited activity against Streptococcus mutans and no activity against Candida albicans and certain strains of Escherichia coli. BHA, at non inhibitory concentrations, increased the microbicidal activity of green tea against 1010 S. mutans (p<0.01), non-susceptible E coli (p<0.01) and C. albicans (p<0.01). Green tea in combination with BHA reduced the hydrophobicity of S. mutans (p<0.01) and greatly inhibited (p<0.001) the formation of hyphae in C. albicans. The increased antimicrobial activity of green tea is related to an impairment of the barrier function in microorganisms and a depletion of thiol groups. The increased activity of green tea as an oral antimicrobial product is discussed.

引用

页码：122 / 127

页数：6

共 31 条

[11]

HUGO WB, 2001, PHARM MICROBIOLOGY

[12] In vivo studies on butylated hydroxyanisole [J].

Iverson, F .

FOOD AND CHEMICAL TOXICOLOGY, 1999, 37 (9-10) :993-997

[13]

KAWABATA S, 1999, METHOD ENZYMOL, P310

[14]

KAYE SB, 1995, AM J MED, V99, P40

[15] Green tea: Biochemical and biological basis for health benefits [J].

Liao, SS ;

Kao, YH ;

Hiipakka, RA .

VITAMINS AND HORMONES - ADVANCES IN RESEARCH AND APPLICATIONS, VOL 62, 2001, 62 :1-94

[16] A NEW TEST BASED ON SALTING OUT TO MEASURE RELATIVE SURFACE HYDROPHOBICITY OF BACTERIAL-CELLS [J].

LINDAHL, M ;

FARIS, A ;

WADSTROM, T ;

HJERTEN, S .

BIOCHIMICA ET BIOPHYSICA ACTA, 1981, 677 (3-4) :471-476

[17] Inhibitory effects of oolong tea extract on caries-inducing properties of mutans streptococci [J].

Matsumoto, M ;

Minami, T ;

Sasaki, H ;

Sobue, S ;

Hamada, S ;

Ooshima, T .

CARIES RESEARCH, 1999, 33 (06) :441-445

[18]

NATIONAL COMMITTEE FOR CLINICAL LABORATORY STANDARDS-NCCLS, 1997, M27A NCCLS

[19]

Odds FC, 1988, CANDIDA CANDIDOSIS R

[20] Inhibition of murine AIDS by reduced glutathione [J].

Palamara, AT ;

Garaci, E ;

Rotilio, G ;

Ciriolo, MR ;

Casabianca, A ;

Fraternale, A ;

Rossi, L ;

Schiavano, GF ;

Chiarantini, L ;

Magnani, M .

AIDS RESEARCH AND HUMAN RETROVIRUSES, 1996, 12 (14) :1373-1381

← 1 2 3 4 →