Global systems biology, personalized medicine and molecular epidemiology

被引:283
作者
Nicholson, Jeremy K. [1 ]
机构
[1] Univ London Imperial Coll Sci Technol & Med, Fac Med, Dept Biomol Med, London, England
关键词
D O I
10.1038/msb4100095
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
引用
收藏
页数:6
相关论文
共 28 条
[11]   Metabolic phenotyping of nude and normal (Alpk:ApfCD, C57BL10J) mice [J].
McKee, CLG ;
Wilson, ID ;
Nicholson, JK .
JOURNAL OF PROTEOME RESEARCH, 2006, 5 (02) :378-384
[12]   Molecular mechanisms of genetic polymorphisms of drug metabolism [J].
Meyer, UA ;
Zanger, UM .
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, 1997, 37 :269-296
[13]  
Nebert Daniel W, 2003, Am J Pharmacogenomics, V3, P361, DOI 10.2165/00129785-200303060-00002
[14]  
NEBERT DW, 2001, PHARMACOGENOMICS, V1, P541
[15]  
NEBERT DW, 2004, PHARMACOGENETICS, V5, P259
[16]   'Metabonomics': understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data [J].
Nicholson, JK ;
Lindon, JC ;
Holmes, E .
XENOBIOTICA, 1999, 29 (11) :1181-1189
[17]   Metabonomics: a platform for studying drug toxicity and gene function [J].
Nicholson, JK ;
Connelly, J ;
Lindon, JC ;
Holmes, E .
NATURE REVIEWS DRUG DISCOVERY, 2002, 1 (02) :153-161
[18]   Understanding 'global' systems biology: Metabonomics and the continuum of metabolism [J].
Nicholson, JK ;
Wilson, ID .
NATURE REVIEWS DRUG DISCOVERY, 2003, 2 (08) :668-676
[19]   Gut microorganisms, mammalian metabolism and personalized health care [J].
Nicholson, JK ;
Holmes, E ;
Wilson, ID .
NATURE REVIEWS MICROBIOLOGY, 2005, 3 (05) :431-438
[20]   The challenges of modeling mammalian biocomplexity [J].
Nicholson, JK ;
Holmes, E ;
Lindon, JC ;
Wilson, ID .
NATURE BIOTECHNOLOGY, 2004, 22 (10) :1268-1274