Synthesis and peptide binding properties of methoxypyrrole amino acids (MOPAS)

被引：24

作者：

Bonauer, C ^{[1
]}

Zabel, M ^{[1
]}

König, B ^{[1
]}

机构：

[1] Univ Regensburg, Inst Organ Chem & Zent Analyt, D-93040 Regensburg, Germany

来源：

ORGANIC LETTERS | 2004年 / 6卷 / 09期

关键词：

D O I：

10.1021/ol049855x

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Methoxypyrrole amino acids (MOPAS) have been prepared and were introduced into small peptides with hairpin structures. The intra- and intermolecular binding properties of this heterocyclic amino acid mimicking a dipeptido beta-strand was investigated by NMR titration and X-ray crystal structure analysis. The data reveal a hydrogen bonding pattern that is complementary to a peptide beta-sheet.

引用

页码：1349 / 1352

页数：4

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