μ2-Alkyne dicobalt(0)hexacarbonyl complexes as carbon monoxide-releasing molecules (CO-RMs): probing the release mechanism

被引：72

作者：

Atkin, Anthony J. ^{[1
]}

Williams, Sophie ^{[1
]}

Sawle, Philip ^{[2
]}

Motterlini, Roberto ^{[2
,3
]}

Lynam, Jason M. ^{[1
]}

Fairlamb, Ian J. S. ^{[1
]}

机构：

[1] Univ York, Dept Chem, York YO10 5DD, N Yorkshire, England

[2] Northwick Pk Inst Med Res, Vasc Biol Unit, Dept Surg Res, Harrow HA1 3UJ, Middx, England

[3] Italian Inst Technol, Dept Drug Discovery & Dev, I-16163 Genoa, Italy

来源：

DALTON TRANSACTIONS | 2009年 / 19期

基金：

英国工程与自然科学研究理事会;

关键词：

COBALT-ALKYNE COMPLEXES; METAL-CARBONYLS; CELLULAR UPTAKE; CYTOTOXICITY; MODULATION; CHEMISTRY;

D O I：

10.1039/b904627p

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The first carbon monoxide-releasing molecules (CO-RMs) based on mu(2)-alkyne dicobalt(0)hexacarbonyl complexes are reported. The alkyne substituents significantly affect the rate of CO-release, cytotoxicity and cell viability. Mechanistic studies provide insight into the CO-RM activation pathways.

引用

页码：3653 / 3656

页数：4

共 33 条

[1] Chemistry and biological activities of CO-releasing molecules (CORMs) and transition metal complexes [J].

Alberto, Roger ;

Motterlini, Roberto .

DALTON TRANSACTIONS, 2007, (17) :1651-1660

[2] Increase in exhaled carbon monoxide during exacerbations of cystic fibrosis [J].

Antuni, JD ;

Kharitonov, SA ;

Hughes, D ;

Hodson, ME ;

Barnes, PJ .

THORAX, 2000, 55 (02) :138-142

[3] Cardioprotective actions by a water-soluble carbon monoxide-releasing molecule [J].

Clark, JE ;

Naughton, P ;

Shurey, S ;

Green, CJ ;

Johnson, TR ;

Mann, BE ;

Foresti, R ;

Motterlini, R .

CIRCULATION RESEARCH, 2003, 93 (02) :E2-E8

[4] The application of polymer-bound carbonylcobalt(0) species in linker chemistry and catalysis [J].

Comely, AC ;

Gibson, SE ;

Hales, NJ ;

Johnstone, C ;

Stevenazzi, A .

ORGANIC & BIOMOLECULAR CHEMISTRY, 2003, 1 (11) :1959-1968

[5] Theoretical study of the regiochemistry-determining step of the Pauson-Khand reaction [J].

de Bruin, TJM ;

Milet, A ;

Robert, F ;

Gimbert, Y ;

Greene, AE .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2001, 123 (29) :7184-7185

[6] h1-2-pyrone metal carbonyl complexes as CO-releasing molecules (CO-RMs):: A delicate balance between stability and CO liberation [J].

Fairlamb, Ian J. S. ;

Lynam, Jason M. ;

Moulton, Benjamin E. ;

Taylor, Ian E. ;

Duhme-Klair, Anne K. ;

Sawle, Philip ;

Motterlini, Roberto .

DALTON TRANSACTIONS, 2007, (33) :3603-3605

[7] η4-Pyrone iron(0)carbonyl complexes as effective CO-releasing molecules (CO-RMs) [J].

Fairlamb, IJS ;

Duhme-Klair, AK ;

Lynam, JM ;

Moulton, BE ;

O'Brien, CT ;

Sawle, P ;

Hammad, J ;

Motterlini, R .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2006, 16 (04) :995-998

[8] Vasoactive properties of CORM-3, a novel water-soluble carbon monoxide-releasing molecule [J].

Foresti, R ;

Hammad, J ;

Clark, JE ;

Johnson, TR ;

Mann, BE ;

Friebe, A ;

Green, CJ ;

Motterlini, R .

BRITISH JOURNAL OF PHARMACOLOGY, 2004, 142 (03) :453-460

[9] Synthesis and Characterization of Dicobalthexacarbonyl-Alkyne Derivatives of Amino Acids, Peptides, and Peptide Nucleic Acid (PNA) Monomers [J].

Gasser, Gilles ;

Neukamm, Merja A. ;

Ewers, Alexandra ;

Brosch, Oliver ;

Weyhermueller, Thomas ;

Metzler-Nolte, Nils .

INORGANIC CHEMISTRY, 2009, 48 (07) :3157-3166

[10] PHASE-TRANSFER CATALYZED REDUCTIONS OF METAL-CARBONYLS [J].

GIBSON, DH ;

AHMED, FU ;

PHILLIPS, KR .

JOURNAL OF ORGANOMETALLIC CHEMISTRY, 1981, 206 (02) :C17-C20

← 1 2 3 4 →