The stem cell secretome and its role in brain repair

被引:276
作者
Drago, Denise [1 ,2 ]
Cossetti, Chiara [3 ,4 ,5 ]
Iraci, Nunzio [3 ,4 ,5 ]
Gaude, Edoardo [6 ]
Musco, Giovanna [6 ]
Bachi, Angela [2 ]
Pluchino, Stefano [1 ,3 ,4 ,5 ]
机构
[1] Ist Sci San Raffaele, Inst Expt Neurol, Div Neurosci, CNS Repair Unit, I-20132 Milan, Italy
[2] Ist Sci San Raffaele, Div Genet & Cell Biol, Biomol Mass Spectrometry Unit, I-20132 Milan, Italy
[3] Univ Cambridge, John van Geest Ctr Brain Repair, Dept Clin Neurosci, Cambridge CB2 0PY, England
[4] Univ Cambridge, Biomed Res Ctr, NIHR, Cambridge CB2 0PY, England
[5] Univ Cambridge, Wellcome Trust Med Res Council Stem Cell Inst, Cambridge CB2 0PY, England
[6] S Raffaele Sci Inst, Dulbecco Telethon Inst, Biomol NMR Lab, Ctr Translat Genom & Bioinformat, Milan, Italy
基金
欧洲研究理事会;
关键词
Secretome; Mesenchymal stem cells; Neural stem cells; Brain repair; Stem cell transplantation; HUMAN BONE-MARROW; NEURAL STEM/PROGENITOR CELLS; MESENCHYMAL STROMAL CELLS; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; NERVE GROWTH-FACTOR; EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS; PEPTIDE NANOFIBER HYDROGEL; T-LYMPHOCYTE PROLIFERATION; FOCAL CEREBRAL-ISCHEMIA; HUMAN ADIPOSE-TISSUE;
D O I
10.1016/j.biochi.2013.06.020
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Compelling evidence exists that non-haematopoietic stem cells, including mesenchymal (MSCs) and neural/progenitor stem cells (NPCs), exert a substantial beneficial and therapeutic effect after transplantation in experimental central nervous system (CNS) disease models through the secretion of immune modulatory or neurotrophic paracrine factors. This paracrine hypothesis has inspired an alternative outlook on the use of stem cells in regenerative neurology. In this paradigm, significant repair of the injured brain may be achieved by injecting the biologics secreted by stem cells (secretome), rather than implanting stem cells themselves for direct cell replacement. The stem cell secretome (SCS) includes cytokines, chemokines and growth factors, and has gained increasing attention in recent years because of its multiple implications for the repair, restoration or regeneration of injured tissues. Thanks to recent improvements in SCS profiling and manipulation, investigators are now inspired to harness the SCS as a novel alternative therapeutic option that might ensure more efficient outcomes than current stem cell-based therapies for CNS repair. This review discusses the most recent identification of MSC- and NPC-secreted factors, including those that are trafficked within extracellular membrane vesicles (EVs), and reflects on their potential effects on brain repair. It also examines some of the most convincing advances in molecular profiling that have enabled mapping of the SCS. (C) 2013 The Authors. Published by Elsevier Masson SAS. All rights reserved.
引用
收藏
页码:2271 / 2285
页数:15
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