Synthesis of the vancomycin CD and DE ring systems

被引：93

作者：

Boger, DL ^{[1
]}

Borzilleri, RM ^{[1
]}

Nukui, S ^{[1
]}

Beresis, RT ^{[1
]}

机构：

[1] Scripps Res Inst, SKAGGS INST CHEM BIOL, LA JOLLA, CA 92037 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1997年 / 62卷 / 14期

关键词：

D O I：

10.1021/jo970560p

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Full details of the synthesis of the fully substituted vancomycin CD and DE ring systems are described and a potential solution to the control of the atropisomer stereochemistry is defined.

引用

页码：4721 / 4736

页数：16

共 123 条

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[13] VANCOMYCIN AND RISTOCETIN MODELS - SYNTHESIS VIA THE ULLMANN MACROCYCLIZATION REACTION
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[14] AN UNUSUALLY FACILE SNAR 14-MEMBERED BIARYL ETHER MACROCYCLIZATION REACTION SUITABLE FOR PREPARATION OF THE CYCLOISODITYROSINE SUBUNIT OF BOUVARDIN, DEOXYBOUVARDIN AND RELATED AGENTS
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[J]. JOURNAL OF ORGANIC CHEMISTRY, 1997, 62 (07) : 2054 - 2069
[16] TOTAL SYNTHESIS OF BOUVARDIN, O-METHYLBOUVARDIN, AND O-METHYL-N-9-DESMETHYLBOUVARDIN
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[18] SYNTHESIS OF N29-DESMETHYL RA-VII - IDENTIFICATION OF THE PHARMACOPHORE OF RA-I-VII AND DEOXYBOUVARDIN AND REASSIGNMENT OF THE SUBUNIT FUNCTIONAL ROLES
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[J]. JOURNAL OF ORGANIC CHEMISTRY, 1992, 57 (05) : 1319 - 1321
[19] TOTAL SYNTHESIS OF CYCLOISODITYROSINE, RA-VII, DEOXYBOUVARDIN, AND N29-DESMETHYL-RA-VII - IDENTIFICATION OF THE PHARMACOPHORE AND REVERSAL OF THE SUBUNIT FUNCTIONAL ROLES
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[20] TOTAL SYNTHESIS OF DEOXYBOUVARDIN AND RA-VII - MACROCYCLIZATION VIA AN INTRAMOLECULAR ULLMANN REACTION
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