Continuous flow chemistry: a discovery tool for new chemical reactivity patterns

被引：55

作者：

Hartwig, Jan ^{[1
]}

Metternich, Jan B. ^{[2
]}

Nikbin, Nikzad ^{[2
]}

Kirschning, Andreas ^{[1
]}

Ley, Steven V. ^{[2
]}

机构：

[1] Leibniz Univ Hannover, Inst Organ Chem, D-30167 Hannover, Germany

[2] Univ Cambridge, Dept Chem, Innovat Technol Ctr, Cambridge CB2 1EW, England

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2014年 / 12卷 / 22期

基金：

英国工程与自然科学研究理事会;

关键词：

MAGNETIC NANOPARTICLES; ENABLING TECHNOLOGY; MULTISTEP SYNTHESIS; ORGANIC-SYNTHESIS; REACTORS; KETONES;

D O I：

10.1039/c4ob00662c

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Continuous flow chemistry as a process intensification tool is well known. However, its ability to enable chemists to perform reactions which are not possible in batch is less well studied or understood. Here we present an example, where a new reactivity pattern and extended reaction scope has been achieved by transferring a reaction from batch mode to flow. This new reactivity can be explained by suppressing back mixing and precise control of temperature in a flow reactor set up.

引用

页码：3611 / 3615

页数：5

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