Catalytic asymmetric reductive amination of aldehydes via dynamic kinetic resolution

被引：339

作者：

Hoffmann, Sebastian ^{[1
]}

Nicoletti, Marcello ^{[1
]}

List, Benjamin ^{[1
]}

机构：

[1] Max Planck Inst Kohlenforsch, D-45470 Mulheim, Germany

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2006年 / 128卷 / 40期

关键词：

D O I：

10.1021/ja065404r

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel organocatalytic asymmetric reductive amination of aldehydes has been developed. Treating racemic α-branched aldehydes with p-anisidine and a Hantzsch ester in the presence of our previously developed phosphoric acid catalyst, TRIP, gave β-branched secondary amines in excellent yields and enantioselectivities via an efficient dynamic kinetic resolution. The process is applicable to several different aromatic aldehydes and amines but gives slightly reduced enantiomeric ratios with aliphatic aldehydes. Copyright © 2006 American Chemical Society.

引用

页码：13074 / 13075

页数：2

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