Copper(I)-catalyzed enantio- and diastereoselective tandem reductive aldol reaction

被引：70

作者：

Chuzel, Olivier ^{[1
]}

Deschamp, Julia ^{[1
]}

Chausteur, Christophe ^{[1
]}

Riant, Olivier ^{[1
]}

机构：

[1] Catholic Univ Louvain, Unite Chim Organ & Med, B-1348 Louvain, Belgium

来源：

ORGANIC LETTERS | 2006年 / 8卷 / 26期

关键词：

D O I：

10.1021/ol062398v

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient method for the enantioselective tandem reductive aldol reaction of methyl acrylate with aldehydes is reported. By using a copper( I) precursor and a proper diphosphane ligand, high reactivities can be reached, with TOF up to 40 000 h(-1). Taniaphos- based ligands lead to enantioselectivities of up to 97% in the case of the major syn diastereoisomer.

引用

页码：5943 / 5946

页数：4

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