Pairwise use of complexity-generating reactions in diversity-oriented organic synthesis

被引：247

作者：

Lee, DS ^{[1
]}

Sello, JK ^{[1
]}

Schreiber, SL ^{[1
]}

机构：

[1] Harvard Univ, Howard Hughes Med Inst, Dept Chem & Chem Biol, Harvard Inst Chem & Cell Biol, Cambridge, MA 02138 USA

来源：

ORGANIC LETTERS | 2000年 / 2卷 / 05期

关键词：

D O I：

10.1021/ol005574n

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] Two pairs of complexity-generating reactions with an essential product-substrate relationship along a synthetic pathway are demonstrated, This pathway illustrates a key element in a planning algorithm for diversity-oriented synthesis, This element facilitates the efficient synthesis of structurally complex compounds, and it can be integrated with ones that provide structurally diverse compounds.

引用

页码：709 / 712

页数：4

共 38 条

[11] Comprehensive survey of combinatorial library synthesis: 1998
Dolle, RE
Nelson, KH
[J]. JOURNAL OF COMBINATORIAL CHEMISTRY, 1999, 1 (04): : 235 - 282
[12] GENERAL-METHOD FOR RAPID SYNTHESIS OF MULTICOMPONENT PEPTIDE MIXTURES
FURKA, A
SEBESTYEN, F
ASGEDOM, M
DIBO, G
[J]. INTERNATIONAL JOURNAL OF PEPTIDE AND PROTEIN RESEARCH, 1991, 37 (06): : 487 - 493
[13] FURKA A, 1988, P 14 INT C BIOCH VSP, V5, P47
[14] HAGGARTY SJ, IN PRESS CHEM BIOL
[15] Combinatorial chemistry. Use of an intramolecular ruthenium catalyzed olefin/alkyne metathesis reaction in tandem with a Diels-Alder cycloaddition reaction to construct functionalized hexahydroisoindoles.
Heerding, DA
Takata, DT
Kwon, C
Huffman, WF
Samanen, J
[J]. TETRAHEDRON LETTERS, 1998, 39 (38) : 6815 - 6818
[16] Solid-phase organic reactions: A review of the recent literature
Hermkens, PHH
Ottenheijm, HCJ
Rees, D
[J]. TETRAHEDRON, 1996, 52 (13) : 4527 - 4554
[17] Solid-phase organic reactions .2. A review of the literature Nov 95 Nov 96.
Hermkens, PHH
Ottenheijm, HCJ
Rees, DC
[J]. TETRAHEDRON, 1997, 53 (16) : 5643 - 5678
[18] GENERATION AND USE OF SYNTHETIC PEPTIDE COMBINATORIAL LIBRARIES FOR BASIC RESEARCH AND DRUG DISCOVERY
HOUGHTEN, RA
PINILLA, C
BLONDELLE, SE
APPEL, JR
DOOLEY, CT
CUERVO, JH
[J]. NATURE, 1991, 354 (6348) : 84 - 86
[19] Olefin metathesis-active ruthenium complexes bearing a nucleophilic carbene ligand
Huang, JK
Stevens, ED
Nolan, SP
Petersen, JL
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1999, 121 (12) : 2674 - 2678
[20] ENCODED COMBINATORIAL PEPTIDE LIBRARIES CONTAINING NONNATURAL AMINO-ACIDS
KERR, JM
BANVILLE, SC
ZUCKERMANN, RN
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1993, 115 (06) : 2529 - 2531

← 1 2 3 4 →