Prognostic Impact of Hypoxia-Inducible miRNA-210 in Patients with Lung Adenocarcinoma

被引：32

作者：

Osugi, Jun ^{[1
]}

Kimura, Yuka ^{[1
]}

Owada, Yuki ^{[1
]}

Inoue, Takuya ^{[1
]}

Watanabe, Yuzuru ^{[1
]}

Yamaura, Takumi ^{[1
]}

Fukuhara, Mitsuro ^{[1
]}

Muto, Satoshi ^{[1
]}

Okabe, Naoyuki ^{[1
]}

Matsumura, Yuki ^{[1
]}

Hasegawa, Takeo ^{[1
]}

Yonechi, Athushi ^{[1
]}

Hoshino, Mika ^{[1
]}

Higuchi, Mitsunori ^{[1
]}

Shio, Yutaka ^{[1
]}

Suzuki, Hiroyuki ^{[1
]}

Gotoh, Mitsukazu ^{[1
]}

机构：

[1] Fukushima Med Univ, Sch Med, Dept Regenerat Surg, Fukushima 9601295, Japan

来源：

JOURNAL OF ONCOLOGY | 2015年 / 2015卷

关键词：

GENE-EXPRESSION; CANCER; MIR-210; MICRORNAS; FACTOR-1-ALPHA; TUMORS; HSA-MIR-210; ANTAGONIST; SIGNATURE; DIAGNOSIS;

D O I：

10.1155/2015/316745

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Objective. The aim of this study was to investigate the prognostic value of MicroRNA-210 (miR-210) expression in patients with non-small-cell lung cancer (NSCLC). Methods. We examined the miR-210 expression of samples of 80 patients, who underwent surgical resection at Fukushima Medical University from 2004 to 2007, by using quantitative RT-PCR. The relationship between miR-210 expression and clinicopathological factors as well as histological subtype was statistically analyzed. Results. miR-210 expression showed an inverse correlation with disease-free and overall survival in patients with NSCLC. Significant correlations were found between miR-210 expression and lymph node metastasis, late disease stages, and poor prognosis in patients with adenocarcinoma. Multivariate Cox analysis indicated that miR-210 expression was an independent prognostic factor for disease-free survival in patients with adenocarcinoma. Conclusions. We showed that miR-210 may be a prognostic biomarker for patients with NSCLC, especially for those with lung adenocarcinoma.

引用

页数：8

共 45 条

[1]

MicroRNAs: Genomics, biogenesis, mechanism, and function (Reprinted from Cell, vol 116, pg 281-297, 2004) [J].

Bartel, David P. .

CELL, 2007, 131 (04) :11-29

[2]

hsa-miR-210 is induced by hypoxia and is an independent prognostic factor in breast cancer [J].

Camps, Carme ;

Buffa, Francesca M. ;

Colella, Stefano ;

Moore, John ;

Sotiriou, Christos ;

Sheldon, Helen ;

Harris, Adrian L. ;

Gleadle, Jonathan M. ;

Ragoussis, Jiannis .

CLINICAL CANCER RESEARCH, 2008, 14 (05) :1340-1348

[3]

MicroRNA-210 Controls Mitochondrial Metabolism during Hypoxia by Repressing the Iron-Sulfur Cluster Assembly Proteins ISCU1/2 [J].

Chan, Stephen Y. ;

Zhang, Ying-Yi ;

Hemann, Craig ;

Mahoney, Christopher E. ;

Zweier, Jay L. ;

Loscalzo, Joseph .

CELL METABOLISM, 2009, 10 (04) :273-284

[4]

Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases [J].

Chen, Xi ;

Ba, Yi ;

Ma, Lijia ;

Cai, Xing ;

Yin, Yuan ;

Wang, Kehui ;

Guo, Jigang ;

Zhang, Yujing ;

Chen, Jiangning ;

Guo, Xing ;

Li, Qibin ;

Li, Xiaoying ;

Wang, Wenjing ;

Zhang, Yan ;

Wang, Jin ;

Jiang, Xueyuan ;

Xiang, Yang ;

Xu, Chen ;

Zheng, Pingping ;

Zhang, Juanbin ;

Li, Ruiqiang ;

Zhang, Hongjie ;

Shang, Xiaobin ;

Gong, Ting ;

Ning, Guang ;

Wang, Jun ;

Zen, Ke ;

Zhang, Junfeng ;

Zhang, Chen-Yu .

CELL RESEARCH, 2008, 18 (10) :997-1006

[5]

Hypoxia-regulated microRNA-210 modulates mitochondrial function and decreases ISCU and COX10 expression [J].

Chen, Z. ;

Li, Y. ;

Zhang, H. ;

Huang, P. ;

Luthra, R. .

ONCOGENE, 2010, 29 (30) :4362-4368

[6]

Antisense inhibition of human miRNAs and indications for an involvement of miRNA in cell growth and apoptosis [J].

Cheng, AM ;

Byrom, MW ;

Shelton, J ;

Ford, LP .

NUCLEIC ACIDS RESEARCH, 2005, 33 (04) :1290-1297

[7]

Restoration of tumour suppressor hsa-miR-145 inhibits cancer cell growth in lung adenocarcinoma patients with epidermal growth factor receptor mutation [J].

Cho, William C. S. ;

Chow, Andrew S. C. ;

Au, Joseph S. K. .

EUROPEAN JOURNAL OF CANCER, 2009, 45 (12) :2197-2206

[8]

MicroRNA Regulation of DNA Repair Gene Expression in Hypoxic Stress [J].

Crosby, Meredith E. ;

Kulshreshtha, Ritu ;

Ivan, Mircea ;

Glazer, Peter M. .

CANCER RESEARCH, 2009, 69 (03) :1221-1229

[9]

Positive prognostic impact of miR-210 in non-small cell lung cancer [J].

Eilertsen, Marte ;

Andersen, Sigve ;

Al-Saad, Samer ;

Richardsen, Elin ;

Stenvold, Helge ;

Hald, Sigurd M. ;

Al-Shibli, Khalid ;

Donnem, Tom ;

Busund, Lill-Tove ;

Bremnes, Roy M. .

LUNG CANCER, 2014, 83 (02) :272-278

[10]

MicroRNA-210 modulates endothelial cell response to hypoxia and inhibits the receptor tyrosine kinase ligand Ephrin-A3 [J].

Fasanaro, Pasquale ;

D'Alessandra, Yuri ;

Di Stefano, Valeria ;

Melchionna, Roberta ;

Romani, Sveva ;

Pompilio, Giulio ;

Capogrossi, Maurizio C. ;

Martelli, Fabio .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2008, 283 (23) :15878-15883

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