β-disubstituted allylic chlorides:: Substrates for the Cu-catalyzed asymmetric SN2′ reaction

被引：61

作者：

Falciola, Caroline A. ^{[1
]}

Tissot-Croset, Karine ^{[1
]}

Alexakis, Alexandre ^{[1
]}

机构：

[1] Univ Geneva, Dept Organ Chem, CH-1211 Geneva 4, Switzerland

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 36期

关键词：

alkylation; allylic compounds; asymmetric catalysis; copper; nucleophilic substitution;

D O I：

10.1002/anie.200601855

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Scope broadened: A previously developed asymmetric Cu-catalyzed allylic substitution can be applied to more substituted allylic patterns. Two classes of β-disubstituted substrates, cinnamyl derivatives and aliphatic endocyclic allylic chlorides, afford excellent regio- and enantioselectivities (see schemes; L* = phosphoramidite ligand). (Chemical Equation Presented). © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：5995 / 5998

页数：4

共 53 条

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