Enzyme-Instructed Molecular Self-assembly Confers Nanofibers and a Supramolecular Hydrogel of Taxol Derivative

被引：349

作者：

Gao, Yuan ^{[1
]}

Kuang, Yi ^{[1
]}

Guo, Zu-Feng ^{[2
]}

Guo, Zhihong ^{[2
]}

Krauss, Isaac J. ^{[1
]}

Xu, Bing ^{[1
]}

机构：

[1] Brandeis Univ, Dept Chem, 415 South St, Waltham, MA 02454 USA

[2] Hong Kong Univ Sci & Technol, Dept Chem, Hong Kong, Peoples R China

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2009年 / 131卷 / 38期

关键词：

GELATION; ANALOGS;

D O I：

10.1021/ja904411z

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

By covalently connecting taxol with a motif that is prone to self-assemble, we successfully generate the precursor (5a), the hydrogelator (5b), and hydrogel of a taxol derivative without compromising the cytotoxic activity of the taxol. This approach promises a general method to create nanofibers of therapeutic molecules that have a dual role, as both the delivery vehicle and the drug, itself.

引用

页码：13576 / 13577

页数：2

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