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The role of galanin in feeding behavior

被引：124
作者：
Crawley, JN [1 ]
机构：
[1] NIMH, Sect Behav Neuropharmacol, Expt Therapeut Branch, Bethesda, MD 20892 USA
来源：
NEUROPEPTIDES | 1999年 / 33卷 / 05期
关键词：
D O I：
10.1054/npep.1999.0049
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Galanin inhibits food consumption in satiated rats. Discovered relatively recently, galanin is a 29-amino-acid neuropeptide, not homologous with any other known peptide. Three G-protein-linked galanin receptor subtypes have been cloned. This review summarizes the mechanisms by which exogenously administered galanin may stimulate ingestion, discusses pharmacological and genetic investigations of the role of endogenous galanin on feeding and body weight, and speculates on the therapeutic potential of non-peptide galanin receptor antagonists for the treatment of appetite disorders. (C) 1999 Harcourt Publishers Ltd.
引用
收藏
页码：369 / 375
页数：7
相关论文
共 67 条
  • [11] ALTERED EXPRESSION OF HYPOTHALAMIC NEUROPEPTIDE MESSENGER-RNAS IN FOOD-RESTRICTED AND FOOD-DEPRIVED RATS
    BRADY, LS
    SMITH, MA
    GOLD, PW
    HERKENHAM, M
    [J]. NEUROENDOCRINOLOGY, 1990, 52 (05) : 441 - 447
  • [12] Strategies and potential molecular targets for obesity treatment
    Campfield, LA
    Smith, FJ
    Burn, P
    [J]. SCIENCE, 1998, 280 (5368) : 1383 - 1387
  • [13] POTENT EFFECTS OF HUMAN GALANIN IN MAN - GROWTH-HORMONE SECRETION AND VAGAL BLOCKADE
    CAREY, DG
    IISMAA, TP
    HO, KY
    RAJKOVIC, IA
    KELLY, J
    KRAEGEN, EW
    FERGUSON, J
    INGLIS, AS
    SHINE, J
    CHISHOLM, DJ
    [J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1993, 77 (01) : 90 - 93
  • [14] GALANIN AND THE GALANIN ANTAGONIST M40 DO NOT CHANGE FAT INTAKE IN A FAT-CHOW CHOICE PARADIGM IN RATS
    CORWIN, RL
    ROWE, PM
    CRAWLEY, JN
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 1995, 269 (03) : R511 - R518
  • [15] GALANIN ANTAGONISTS BLOCK GALANIN-INDUCED FEEDING IN THE HYPOTHALAMUS AND AMYGDALA OF THE RAT
    CORWIN, RL
    ROBINSON, JK
    CRAWLEY, JN
    [J]. EUROPEAN JOURNAL OF NEUROSCIENCE, 1993, 5 (11) : 1528 - 1533
  • [16] CRAWFORD RD, 1995, WORLD AN C, V9, P1
  • [17] GALANIN RECEPTOR ANTAGONIST-M40 AND ANTAGONIST-C7 BLOCK GALANIN-INDUCED FEEDING
    CRAWLEY, JN
    ROBINSON, JK
    LANGEL, U
    BARTFAI, T
    [J]. BRAIN RESEARCH, 1993, 600 (02) : 268 - 272
  • [18] CRAWLEY JN, 1990, J NEUROSCI, V10, P3695
  • [19] CRAWLEY JN, UNPUB
  • [20] CRAWLEY JN, 1991, GALANIN NEW MULTIFUN, V58, P377
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