The role of galanin in feeding behavior

被引：124

作者：

Crawley, JN ^{[1
]}

机构：

[1] NIMH, Sect Behav Neuropharmacol, Expt Therapeut Branch, Bethesda, MD 20892 USA

来源：

NEUROPEPTIDES | 1999年 / 33卷 / 05期

关键词：

D O I：

10.1054/npep.1999.0049

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Galanin inhibits food consumption in satiated rats. Discovered relatively recently, galanin is a 29-amino-acid neuropeptide, not homologous with any other known peptide. Three G-protein-linked galanin receptor subtypes have been cloned. This review summarizes the mechanisms by which exogenously administered galanin may stimulate ingestion, discusses pharmacological and genetic investigations of the role of endogenous galanin on feeding and body weight, and speculates on the therapeutic potential of non-peptide galanin receptor antagonists for the treatment of appetite disorders. (C) 1999 Harcourt Publishers Ltd.

引用

页码：369 / 375

页数：7

共 67 条

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