Colorimetric SNP analysis using oligonucleotide-modified nanoparticles

被引：15

作者：

Ihara, T ^{[1
]}

Chikaura, Y ^{[1
]}

Tanaka, S ^{[1
]}

Jyo, A ^{[1
]}

机构：

[1] Kumamoto Univ, Fac Engn, Dept Appl Chem & Biochem, Kumamoto 8608555, Japan

来源：

CHEMICAL COMMUNICATIONS | 2002年 / 18期

关键词：

D O I：

10.1039/b206158a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A point mutation in the p53 gene has been detected by means of fluorescence microscopy and fluorescent resonance energy transfer (FRET) through sequence selective aggregation of DNA-modified nanoparticles, in which fluorescent dyes were impregnated.

引用

页码：2152 / 2153

页数：2

共 14 条

[1]

CANTOR CR, 1980, BIOPHYSICAL CHEM 2

[2] Pharmacogenomics: Translating functional genomics into rational therapeutics [J].

Evans, WE ;

Relling, MV .

SCIENCE, 1999, 286 (5439) :487-491

[3] Gene sensor using ferrocenyl oligonucleotide [J].

Ihara, T ;

Nakayama, M ;

Murata, M ;

Nakano, K ;

Maeda, M .

CHEMICAL COMMUNICATIONS, 1997, (17) :1609-1610

[4] Aggregation of DNA-modified nanospheres depending on added polynucleotides [J].

Ihara, T ;

Kurohara, K ;

Jyo, A .

CHEMISTRY LETTERS, 1999, (10) :1041-1042

[5] Metal ion-directed cooperative triple helix formation of glutamic acid-oligonucleotide conjugate [J].

Ihara, T ;

Takeda, Y ;

Jyo, A .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2001, 123 (08) :1772-1773

[6]

KISHIMOTO Y, 1992, CANCER RES, V52, P4799

[7] THE P53 TUMOR SUPPRESSOR GENE [J].

LEVINE, AJ ;

MOMAND, J ;

FINLAY, CA .

NATURE, 1991, 351 (6326) :453-456

[8] Twenty years of p53 research: structural and functional aspects of the p53 protein [J].

May, P ;

May, E .

ONCOGENE, 1999, 18 (53) :7621-7636

[9]

NIEMEYER CM, 2000, ANGEW CHEM, V112, P3138

[10]

PARK SJ, 2000, ANGEW CHEM, V112, P4003

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