Serum angiogenic activity: Diagnostic relevance in renal cell carcinoma

被引:10
作者
Beecken, WD [1 ]
Bentas, W [1 ]
Glienke, W [1 ]
Linneweber, J [1 ]
Jonas, D [1 ]
Binder, J [1 ]
Kramer, W [1 ]
机构
[1] Univ Frankfurt, Clin Urol & Pediat Urol, D-60590 Frankfurt, Germany
关键词
renal cell carcinoma; angiogenesis; stimulation; angiogenic activity;
D O I
10.1016/S0302-2838(02)00359-7
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Objective: Angiogenesis is essential for tumor growth and progression. However, reported data on angiogenic parameters in patients with renal cell carcinoma are contradictory. The objective of this study was to use serum to compare the systemic angiogenic activity in patients with renal cell carcinoma and to determine if pathologic stage and grade correlated to this angiogenesis parameter. Methods: Serum of 28 patients with a newly diagnosed renal cell carcinoma, 28 healthy volunteers and 9 patients with bladder carcinoma were used for this study. All sera were tested in a 72-hour endothelial cell proliferation assay. In addition the serum concentrations of the angiogenesis stimulators basic fibroblast growth factor (bFGF) and vascular endothelial growth factor (VEGF) were determined using standard ELISA assays. Results: The serum of renal cell carcinoma patients showed a median stimulation of human umbilical vein endothelial cells (HUVEC) of 89.79% (range 58.47-147.95%) and serum of healthy volunteers showed a median stimulation of 95.35% (range 74.64-141.77%) (p > 0.05). In contrast serum of patients with bladder carcinoma showed a median stimulation of 140.16% (range 64.82-200.16%) (p = 0.024). No correlations of the serum angiogenic activity and tumor stage or grade have been found in renal cell carcinoma patients. Furthermore, no correlations for serum bFGF and VEGF concentrations have been found. Conclusions: Serum angiogenic activity of patients with renal cell carcinoma did not differ significantly from healthy controls, while serum of patients with bladder carcinoma showed a significant increase in endothelial cell stimulation. Furthermore, bFGF and VEGF serum concentrations did not correlate to serum angiogenic activity in patients with renal cell carcinoma. Therefore, the determination of systemic angiogenic parameters, in case of renal cell carcinoma, might not lead to adequate data concerning prognosis or therapeutic effects. (C) 2002 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:364 / 369
页数:6
相关论文
共 25 条
  • [11] Clinical significance of tumor angiogenesis in patients with localized renal cell carcinoma
    Nativ, O
    Sabo, E
    Reiss, A
    Wald, M
    Madjar, S
    Moskovitz, B
    [J]. UROLOGY, 1998, 51 (05) : 693 - 696
  • [12] Obermair A, 1997, INT J CANCER, V74, P455, DOI 10.1002/(SICI)1097-0215(19970822)74:4<455::AID-IJC17>3.0.CO
  • [13] 2-8
  • [14] ANGIOSTATIN - A NOVEL ANGIOGENESIS INHIBITOR THAT MEDIATES THE SUPPRESSION OF METASTASES BY A LEWIS LUNG-CARCINOMA
    OREILLY, MS
    HOLMGREN, L
    SHING, Y
    CHEN, C
    ROSENTHAL, RA
    MOSES, M
    LANE, WS
    CAO, YH
    SAGE, EH
    FOLKMAN, J
    [J]. CELL, 1994, 79 (02) : 315 - 328
  • [15] Expression of vascular endothelial growth factor in renal cell carcinomas
    Paradis, V
    Ben Lagha, N
    Zeimoura, L
    Blanchet, P
    Eschwege, P
    Ba, N
    Benoît, G
    Jardin, A
    Bedossa, P
    [J]. VIRCHOWS ARCHIV, 2000, 436 (04) : 351 - 356
  • [16] Pavlopoulos PM, 1998, CANCER, V83, P2067, DOI 10.1002/(SICI)1097-0142(19981115)83:10<2067::AID-CNCR4>3.0.CO
  • [17] 2-Q
  • [18] Sabo E, 2001, CLIN CANCER RES, V7, P533
  • [19] Vascular endothelial growth factor - Its relation to neovascularization and their significance as prognostic factors in renal cell carcinoma
    Song, KH
    Song, J
    Jeong, GB
    Kim, JM
    Jung, SH
    Song, J
    [J]. YONSEI MEDICAL JOURNAL, 2001, 42 (05) : 539 - 546
  • [20] Vascular endothelial growth factor-C expression in human prostatic carcinoma and its relationship to lymph node metastasis
    Tsurusaki, T
    Kanda, S
    Sakai, H
    Kanetake, H
    Saito, Y
    Alitalo, K
    Koji, T
    [J]. BRITISH JOURNAL OF CANCER, 1999, 80 (1-2) : 309 - 313