Total synthesis of (+)-hygrine via asymmetric phase-transfer catalytic alkylation

被引：29

作者：

Lee, Jeong-Hee

Jeong, Byeong-Seon

Ku, Jin-Mo

Jew, Sang-sup ^{[1
]}

Park, Hyeung-geun

机构：

[1] Seoul Natl Univ, Res Inst Pharmaceut Sci, Seoul 151742, South Korea

[2] Seoul Natl Univ, Coll Pharm, Seoul 151742, South Korea

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2006年 / 71卷 / 17期

关键词：

D O I：

10.1021/jo061108l

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first enantioselective synthesis of (+)- hygrine ( 1) is reported. 1 was obtained in 12 steps with 29% overall yield and 97% ee via asymmetric phase-transfer catalytic alkylation and ring-closing metathesis as key steps. The absolute configuration of (+)- hygrine could be directly confirmed as R.

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页码：6690 / 6692

页数：3

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