A Fluorescence "Turn-On" Ensemble for Acetylcholinesterase Activity Assay and Inhibitor Screening

被引:104
作者
Peng, Lihua [1 ]
Zhang, Guanxin [1 ]
Zhang, Deqing [1 ]
Xiang, Junfeng [1 ]
Zhao, Rui [1 ]
Wang, Yilin [1 ]
Zhu, Daoben [1 ]
机构
[1] Chinese Acad Sci, Inst Chem, Beijing Natl Lab Mol Sci, Organ Solids Lab, Beijing 100190, Peoples R China
关键词
AGGREGATION-INDUCED EMISSION; PROBES;
D O I
10.1021/ol9016723
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
By making use of the aggregation-induced emission feature of compound 1 and the cascade reactions among acetylthiocholine iodide (ATC), AChE, and compound 2, a new fluorescence "turn-on" method is developed for AChE assay and inhibitor-screening.
引用
收藏
页码:4014 / 4017
页数:4
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