Cephalostatin support studies. Part 19. Outer-ring stereochemical modulation of cytotoxicity in cephalostatins

被引：29

作者：

LaCour, TG ^{[1
]}

Guo, CX

Boyd, MR

Fuchs, PL

机构：

[1] Purdue Univ, Dept Chem, W Lafayette, IN 47907 USA

[2] NCI, Frederick Canc Res Ctr, Frederick, MD 21702 USA

来源：

ORGANIC LETTERS | 2000年 / 2卷 / 01期

关键词：

D O I：

10.1021/ol991153y

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] 20- and 25'-epimers of cephalostatin 7, prepared by directed unsymmetrical pyrazine synthesis, address outer-ring topographical and stability questions and intimate an oxacarbenium ion rationale for the role in bioactivity of the spiroketal (E/F, E'/F') rings of this class of antitumor agents.

引用

页码：33 / 36

页数：4

共 24 条

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