Heparin-induced thrombocytopenia

被引：70

作者：

Lee, Grace M. ^{[1
]}

Arepally, Gowthami M. ^{[1
]}

机构：

[1] Duke Univ, Med Ctr, Dept Med, Div Hematol, Durham, NC 27710 USA

来源：

HEMATOLOGY-AMERICAN SOCIETY OF HEMATOLOGY EDUCATION PROGRAM | 2013年

基金：

美国国家卫生研究院;

关键词：

OPTICAL-DENSITY; DIAGNOSIS; ANTIBODIES; THROMBOSIS; SCORE; SPECIFICITY; RELEASE; ELISA; STEP;

D O I：

10.1182/asheducation-2013.1.668

中图分类号：

G40 [教育学];

学科分类号：

040101 ; 120403 ;

摘要：

Heparin-induced thrombocytopenia (HIT) is a prothrombotic disorder caused by antibodies that recognize complexes of platelet factor 4 (PF4) and heparin. HIT is frequently considered in the differential diagnosis of thrombocytopenia occurring in patients on heparin therapy. HIT is a challenging diagnosis because of routine heparin use in hospitalized patients, the common occurrence of thrombocytopenia, and high rates of anti-PF4/heparin seroconversions in patients treated with heparin. Our diagnostic approach to HIT is presented here, underscoring critical elements of clinical and laboratory evaluation.

引用

页码：668 / 674

页数：7

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