1-(α-Boc-aminoacyl)benzotriazoles:: Stable chiral α-aminoacylation reagents

被引：60

作者：

Katritzky, AR ^{[1
]}

Wang, MY ^{[1
]}

Yang, HF ^{[1
]}

Zhang, SM ^{[1
]}

Akhmedov, NG ^{[1
]}

机构：

[1] Univ Florida, Dept Chem, Ctr Heterocycl Cpds, Gainesville, FL 32611 USA

来源：

ARKIVOC | 2002年

关键词：

alpha-(N-Boc-aminoacyl)benzotriazoles; alpha-aminoacylation;

D O I：

10.3998/ark.5550190.0003.814

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The chiral alpha-N-(tert-butoxycarbonyl)aminoacylbenzotriazoles [(N-Boc-aminoacyl)-benzotriazoles] 3a-e are stable crystalline intermediates, easily prepared (61-88%) from N-Boc-alpha-amino acids 1a-e. Compounds 3a-e react with achiral or chiral amines at 0-20 degreesC to give alpha-(N-Boc-amino)amides with no detectable racemization.

引用

页码：134 / 142

页数：9

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