Formal total synthesis of camptothecin via ring-closing metathesis strategy

被引：36

作者：

Chavan, SP ^{[1
]}

Pasupathy, K ^{[1
]}

Venkatraman, MS ^{[1
]}

Kale, RR ^{[1
]}

机构：

[1] Natl Chem Lab, Div Organ Chem Technol, Pune 411008, Maharashtra, India

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 37期

关键词：

anticancer; camptothecin; ring-closing metathesis (RCM); pyridone;

D O I：

10.1016/j.tetlet.2004.07.101

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A formal total synthesis of camptothecin 1 is presented. The key steps include construction of the D-ring of camptothecin featuring an efficient ring-closing metathesis (RCM) reaction and the subsequent Michael addition of nitropropane across the double bond of the dihydropyridone 3. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：6879 / 6882

页数：4

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