Interactions of commensal and pathogenic microorganisms with the intestinal mucosal barrier

被引：541

作者：

Martens, Eric C. ^{[1
]}

Neumann, Mareike ^{[2
]}

Desai, Mahesh S. ^{[2
,3
,4
]}

机构：

[1] Univ Michigan, Med Sch, Ann Arbor, MI 48109 USA

[2] Luxembourg Inst Hlth, Dept Infect & Immun, Esch Sur Alzette, Luxembourg

[3] Univ Southern Denmark, Odense Univ Hosp, Dept Dermatol, Odense Res Ctr Anaphylaxis, Odense, Denmark

[4] Univ Southern Denmark, Odense Univ Hosp, Allergy Ctr, Odense, Denmark

来源：

NATURE REVIEWS MICROBIOLOGY | 2018年 / 16卷 / 08期

基金：

美国国家卫生研究院;

关键词：

CHAIN FATTY-ACIDS; COLONIC MUCUS BARRIER; GUT MICROBIOTA; CLOSTRIDIUM-DIFFICILE; SALMONELLA-TYPHIMURIUM; ANTIBIOTIC-TREATMENT; TUFT CELLS; E-CADHERIN; YERSINIA-PSEUDOTUBERCULOSIS; SPATIAL SEGREGATION;

D O I：

10.1038/s41579-018-0036-x

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The intestinal mucosal barrier is composed of epithelial cells that are protected by an overlying host-secreted mucous layer and functions as the first line of defence against pathogenic and non-pathogenic microorganisms. Some microorganisms have evolved strategies to either survive in the mucosal barrier or circumvent it to establish infection. In this Review, we discuss the current state of knowledge of the complex interactions of commensal microorganisms with the intestinal mucosal barrier, and we discuss strategies used by pathogenic microorganisms to establish infection by either exploiting different epithelial cell lineages or disrupting the mucous layer, as well as the role of defects in mucus production in chronic disease.

引用

收藏

页码：457 / 470

页数：14

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