Observations on the reaction of N-alkyloxazolidines, isocyanides and carboxylic acids:: A novel three-component reaction leading to N-acyloxyethylamino acid amides

被引：14

作者：

Diorazio, Louis J.

Motherwell, William B.

Sheppard, Tom D.

Waller, Robert W.

机构：

[1] UCL, Dept Chem, Christopher Ingold Labs, London WC1H 0AJ, England

[2] AstraZeneca, AstraZeneca Proc R&D, Macclesfield SK10 2NA, Cheshire, England

来源：

SYNLETT | 2006年 / 14期

关键词：

amino alcohols; carboxylic acids; heterocycles; multicomponent reactions; ring opening;

D O I：

10.1055/s-2006-950413

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

N-Alkyloxazolidines, readily prepared by condensation of the parent carbonyl compounds with beta-aminoalcohols, were found to undergo three-component reactions with isocyanides and carboxylic acids to give N-acyloxyethylamino acid derivatives in good yield. The reaction allows the variation of substituents at five different sites in the products through suitable choice of reagents.

引用

页码：2281 / 2283

页数：3

共 20 条

[1] THE CLEAVAGE OF OXAZOLIDINES BY LITHIUM ALUMINUM HYDRIDE [J].