Biosynthesis of isoprenoids via the non-mevalonate pathway

被引：497

作者：

Eisenreich, W

Bacher, A

Arigoni, D

Rohdich, F

机构：

[1] Tech Univ Munich, Lehrstuhl Organ Chem & Biochem, D-85747 Garching, Germany

[2] ETH, HCI, Organ Chem Lab, CH-8093 Zurich, Switzerland

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2004年 / 61卷 / 12期

关键词：

isoprenoid biosynthesis; terpenes; retrobiosynthetic analysis; isopentenyl diphosphate; dimethylallyl diphosphate; mevalonate; deoxyxylulose; methylerythritol;

D O I：

10.1007/s00018-004-3381-z

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The mevalonate pathway for the biosynthesis of the universal terpenoid precursors, isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), is known in considerable detail. Only recently, the existence of a second mevalonate-independent pathway for the biosynthesis of IPP and DMAPP was detected in plants and certain eubacteria. Experiments with C-13 and/or H-2-labelled precursors were crucial in the elucidation of this novel route. The pathway is essential in plants, many eubacteria and apicomplexan parasites, but not in archaea and animals. The genes, enzymes and intermediates of this pathway were rapidly unravelled over the past few years. Detailed knowledge about the mechanisms of this novel route may benefit the development of novel antibiotics, antimalarials and herbicides.

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页码：1401 / 1426

页数：26

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