A mild method for the preparation of γ-hydroxy-α,β-acetylenic esters

被引：67

作者：

Shahi, SP ^{[1
]}

Koide, K ^{[1
]}

机构：

[1] Univ Pittsburgh, Dept Chem, Pittsburgh, PA 15260 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2004年 / 43卷 / 19期

关键词：

alcohols; aldehydes; alkynylation; silver; zirconium;

D O I：

10.1002/anie.200353400

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The beauty of silver has been demonstrated in the alkynylation of functionalized aldehydes and ketones. Silver acetylides of alkynyl propiolates undergo addition to carbonyl compounds in the presence of [Cp 2ZrCl2] and AgOTf (see scheme) in a reaction that is compatible with both base-sensitive and acid-sensitive functional groups. Tf = trifluoromethanesulfonyl.

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收藏

页码：2525 / 2527

页数：3

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