Recycling endosomes supply AMPA receptors for LTP

被引：567

作者：

Park, M

Penick, EC

Edwards, JG

Kauer, JA

Ehlers, MD

机构：

[1] Duke Univ, Med Ctr, Dept Neurobiol, Durham, NC 27710 USA

[2] Duke Univ, Med Ctr, Dept Cell Biol, Durham, NC 27710 USA

[3] Duke Univ, Med Ctr, Dept Pharmacol & Canc Biol, Durham, NC 27710 USA

[4] Duke Univ, Med Ctr, Dept Pathol, Durham, NC 27710 USA

[5] Duke Univ, Med Ctr, Neuroproteom Lab, Durham, NC 27710 USA

[6] Brown Univ, Dept Mol Pharmacol Physiol & Biotechnol, Providence, RI 02912 USA

来源：

SCIENCE | 2004年 / 305卷 / 5692期

关键词：

D O I：

10.1126/science.1102026

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Long-term potentiation (LTP) of synaptic strength, the most established cellular model of information storage in the brain, is expressed by an increase in the number of postsynaptic AMPA receptors. However, the source of AMPA receptors mobilized during LTP is unknown. We report that AMPA receptors are transported from recycling endosomes to the plasma membrane for LTP. Stimuli that triggered LTP promoted not only AMPA receptor insertion but also generalized recycling of cargo and membrane from endocytic compartments. Thus, recycling endosomes supply AMPA receptors for LTP and provide a mechanistic link between synaptic potentiation and membrane remodeling during synapse modification.

引用

页码：1972 / 1975

页数：4

共 30 条

[21] Transient synaptic activation of NMDA receptors leads to the insertion of native AMPA receptors at hippocampal neuronal plasma membranes [J].