Solventless clay-promoted Friedel-Crafts reaction of indoles with α-amido sulfones:: Unexpected synthesis of 3-(1-arylsulfonylalkyl) indoles

被引：110

作者：

Ballini, Roberto ^{[1
]}

Palmieri, Alessandro ^{[1
]}

Petrini, Marino ^{[1
]}

Torregiani, Elisabetta ^{[1
]}

机构：

[1] Univ Camerino, Dipartimento Sci Chim, I-62032 Camerino, Italy

来源：

ORGANIC LETTERS | 2006年 / 8卷 / 18期

关键词：

D O I：

10.1021/ol061604w

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Friedel-Crafts reaction of indoles with alpha-amido sulfones in the presence of montmorillonite K-10 leads unexpectedly to 3-(1-arylsulfonylalkyl) indoles in good yield. The obtained products can be further desulfonylated under reductive or alkylative conditions giving linear and branched 3-substituted indoles.

引用

页码：4093 / 4096

页数：4

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