The GW182 protein family in animal cells: New insights into domains required for miRNA-mediated gene silencing

被引：150

作者：

Eulalio, Ana ^{[1
]}

Tritschler, Felix ^{[1
]}

Izaurralde, Elisa ^{[1
]}

机构：

[1] Max Planck Inst Dev Biol, Dept Biochem, D-72076 Tubingen, Germany

来源：

RNA | 2009年 / 15卷 / 08期

关键词：

Argonaute; GW182; miRNAs; mRNA decay; P-bodies; RBD; RRM; TNRC6A; MESSENGER-RNA DEGRADATION; P-BODIES; ARGONAUTE; IDENTIFICATION; REPRESSION; MICRORNAS; RECOGNITION; MECHANISMS; COMPONENT; COMPLEX;

D O I：

10.1261/rna.1703809

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

GW182 family proteins interact directly with Argonaute proteins and are required for miRNA-mediated gene silencing in animal cells. The domains of the GW182 proteins have recently been studied to determine their role in silencing. These studies revealed that the middle and C-terminal regions function as an autonomous domain with a repressive function that is independent of both the interaction with Argonaute proteins and of P-body localization. Such findings reinforce the idea that GW182 proteins are key components of miRNA repressor complexes in metazoa.

引用

页码：1433 / 1442

页数：10

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