High-Throughput Experimentation Platform: Parallel Microwave Chemistry in HPLC/GC Vials

被引：37

作者：

Damm, Markus

Kappe, C. Oliver ^{[1
]}

机构：

[1] Karl Franzens Univ Graz, CDLMC, A-8010 Graz, Austria

来源：

JOURNAL OF COMBINATORIAL CHEMISTRY | 2009年 / 11卷 / 03期

关键词：

ASSISTED ORGANIC-SYNTHESIS; FATTY-ACID; 1,3-DICARBONYL COMPOUNDS; ACTIVE METHYLENES; HEATING ELEMENTS; HINDERED ESTERS; DRUG DISCOVERY; ALCOHOLS; TRANSFORMATIONS; WATER;

D O I：

10.1021/cc900007w

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A high-throughput reaction platform for performing parallel microwave chemistry in sealed HPLC/GC vials is described. The system consists of a strongly microwave-absorbing silicon carbide plate with 20 cylindrical wells of appropriate dimensions to be fitted with standard HPLC/GC autosampler vials serving as reaction vessels. In combination with an aluminum sealing plate the setup can be used for microwave processing reaction volumes from 0.5-1.5 mL at a maximum temperature/pressure limit of 250 degrees C/20 bar. The parallel reaction platform displays excellent temperature and reaction homogeneity and has been used for high-throughput reaction optimization studies involving the parallel screening of catalyst, solvent and substrate reactivity for esterification reactions and metal-catalyzed dehydrative C-C couplings.

引用

页码：460 / 468

页数：9

共 45 条

[41] Heteropoly acid-catalyzed highly efficient alkylation of 1,3-dicarbonyl compounds with benzylic and propargylic alcohols [J].