Transesterification of alkylphosphate esters by phospolipase D

被引：3

作者：

Aurich, I ^{[1
]}

Durrschmidt, P ^{[1
]}

Hirche, F ^{[1
]}

UlbrichHofmann, R ^{[1
]}

机构：

[1] UNIV HALLE WITTENBERG,DEPT BIOCHEM BIOTECHNOL,D-6099 HALLE,GERMANY

来源：

BIOTECHNOLOGY LETTERS | 1997年 / 19卷 / 09期

关键词：

D O I：

10.1023/A:1018389621064

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Phospholipase D from cabbage or Streptomyces chromofuscus catalyses the transesterification of alkylphosphate esters, which are potent antitumor agents. The exchange of choline in octadecylphosphosphocholine by N-(2-hydroxyethyl)-N-methylpiperidine with phospholipase D from cabbage is kinetically controlled and amounts to maximum 60% in buffer, 43% in buffer/n-hexane, and 82% in buffer/n-hexane/1-octanol.

引用

页码：875 / 879

页数：5

共 13 条

[1] HALO LIPIDS .10. SYNTHESIS AND CYTOSTATIC ACTIVITY OF O-ALKYLGLYCEROPHOSPHO-L-SERINE ANALOGS [J].

BRACHWITZ, H ;

LANGEN, P ;

DUBE, G ;

SCHILDT, J ;

PALTAUF, F ;

HERMETTER, A .

CHEMISTRY AND PHYSICS OF LIPIDS, 1990, 54 (02) :89-98

[2]

BRACHWITZ H, 1989, Patent No. 10370

[3] ALKYLPHOSPHOCHOLINES - A NEW CLASS OF MEMBRANE-ACTIVE ANTICANCER AGENTS [J].

HILGARD, P ;

KLENNER, T ;

STEKAR, J ;

UNGER, C .

CANCER CHEMOTHERAPY AND PHARMACOLOGY, 1993, 32 (02) :90-95

[4] Enzymatic introduction of N-heterocyclic and As-containing head groups into glycerophospholipids [J].

Hirche, F ;

Schierhorn, A ;

Scherer, G ;

UlbrichHofmann, R .

TETRAHEDRON LETTERS, 1997, 38 (08) :1369-1370

[5] The influence of organic solvents on phospholipid transformations by phospholipase D in emulsion systems [J].

Hirche, F ;

Koch, MHJ ;

Konig, S ;

Wadewitz, T ;

UlbrichHofmann, R .

ENZYME AND MICROBIAL TECHNOLOGY, 1997, 20 (06) :453-461

[6] PRODUCTION OF VARIOUS PHOSPHATIDYLSACCHARIDES BY PHOSPHOLIPASE-D FROM ACTINOMADURA SP STRAIN NO 362 [J].

KOKUSHO, Y ;

TSUNODA, A ;

KATO, S ;

MACHIDA, H ;

IWASAKI, S .

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 1993, 57 (08) :1302-1305

[7] ALKYLPHOSPHOCHOLINES - INFLUENCE OF STRUCTURAL VARIATION ON BIODISTRIBUTION AT ANTINEOPLASTICALLY ACTIVE CONCENTRATIONS [J].

KOTTING, J ;

BERGER, MR ;

UNGER, C ;

EIBL, H .

CANCER CHEMOTHERAPY AND PHARMACOLOGY, 1992, 30 (02) :105-112

[8] SYNTHESIS OF 6-PHOSPHATIDYL-L-ASCORBIC ACID BY PHOSPHOLIPASE-D [J].

NAGAO, A ;

ISHIDA, N ;

TERAO, J .

LIPIDS, 1991, 26 (05) :390-394

[9]

SHUTO S, 1988, CHEM PHARM BULL, V36, P209

[10] ANTINEOPLASTIC ACTIVITY AND TOLERABILITY OF A NOVEL HETEROCYCLIC ALKYLPHOSPHOLIPID, D-20133 [J].

STEKAR, J ;

HILGARD, P ;

VOEGELI, R ;

MAURER, HR ;

ENGEL, J ;

KUTSCHER, B ;

NOSSNER, G ;

SCHUMACHER, W .

CANCER CHEMOTHERAPY AND PHARMACOLOGY, 1993, 32 (06) :437-444

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