Molecularly imprinted polymers for tobacco mosaic virus recognition

被引：93

作者：

Bolisay, Linden D.

Culver, James N.

Kofinas, Peter ^{[1
]}

机构：

[1] Univ Maryland, Dept Chem & Biomol Engn, College Pk, MD 20742 USA

[2] Univ Maryland, Inst Biotechnol, Ctr Biosyst Res, College Pk, MD 20742 USA

来源：

BIOMATERIALS | 2006年 / 27卷 / 22期

关键词：

hydrogel; molecular imprinting; virus;

D O I：

10.1016/j.biomaterials.2006.03.018

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Molecular imprinted Polymers (MIP) targeted for Tobacco mosaic virus (TMV) have been synthesized. Batch equilibrium studies using imprinted and non-imprinted polymer hydrogels in TMV and TNV solutions were conducted to determine virus-binding capacities. TMV-imprinted hydrogels showed increased binding to TMV (8.8 mg TMV/g polymer) compared to non-imprinted hydrogels (4.2 mg TMV/g polymer). Furthermore, TMV-imprinted hydrogels exhibited increased binding to TMV compared to TNV, while nonimprinted hydrogels bound similar amounts of TMV or TNV. This research has demonstrated that molecular imprinting of viruses can be used to selectively induce binding of target viruses based on shape differences of their virions. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：4165 / 4168

页数：4

共 14 条

[1] A molecular imprinted polymer with recognition properties towards the carcinogenic mycotoxin ochratoxin A [J].