Synthesis of Oxindoles by Palladium-catalyzed C-H Bond Amidation

被引：42

作者：

Miura, Tomoya ^{[1
]}

Ito, Yoshiteru ^{[1
]}

Murakami, Masahiro ^{[1
]}

机构：

[1] Kyoto Univ, Dept Synthet Chem & Biol Chem, Kyoto 6158510, Japan

来源：

CHEMISTRY LETTERS | 2009年 / 38卷 / 04期

关键词：

3,3-DISUBSTITUTED OXINDOLES; ACTIVATION REACTIONS; FUNCTIONALIZATION; HETEROCYCLES; CARBAZOLES; AMINATION; ROUTE;

D O I：

10.1246/cl.2009.328

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Treatment of N-tosylphenylacetamide derivatives with copper(II) acetate in the presence of a catalytic amount of palladium(II) acetate affords 3,3-disubstituted oxindoles. The reaction proceeds through the intramolecular metallation of an aromatic C-H bond and the following C-N bond formation by reductive elimination.

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页码：328 / 329

页数：2

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