Saccharomyces cerevisiae basic helix-loop-helix proteins regulate diverse biological processes

被引：101

作者：

Robinson, KA

Lopes, JM

机构：

[1] Wayne State Univ, Dept Biol Sci, Detroit, MI 48202 USA

[2] Loyola Univ, Dept Mol & Cellular Biochem, Maywood, IL 60153 USA

来源：

NUCLEIC ACIDS RESEARCH | 2000年 / 28卷 / 07期

关键词：

D O I：

10.1093/nar/28.7.1499

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Basic helix-loop-helix (bHLH) proteins are among the most well studied and functionally important regulatory proteins in all eukaryotes. The HLH domain dictates dimerization to create homo- and heterodimers. Dimerization juxtaposes the basic regions of the two monomers to create a DNA interaction surface that recognizes the consensus sequence called the E-box, 5'-CANNTG-3'. Several bHLH proteins have been identified in the yeast Saccharomyces cerevisiae using traditional genetic methodologies. These proteins regulate diverse biological pathways. The completed sequence of the yeast genome, combined with novel methodologies allowing whole-genome expression studies, now offers a unique opportunity to study the function of these bHLH proteins. It is the purpose of this review to summarize the current knowledge of bHLH protein function in yeast.

引用

页码：1499 / 1505

页数：7

共 64 条

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