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RuCl2(DMSO)4 catalyzes the β-alkylation of secondary alcohols with primary alcohols through a hydrogen autotransfer process

被引：147
作者：
Martinez, Ricardo
Ramon, Diego J.
Yus, Miguel
机构：
[1] Univ Alicante, Fac Ciencias, ISO, E-03080 Alicante, Spain
[2] Univ Alicante, Fac Ciencias, Dept Quim Organ, E-03080 Alicante, Spain
来源：
TETRAHEDRON | 2006年 / 62卷 / 38期
关键词：
D O I：
10.1016/j.tet.2006.07.012
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The electrophilic beta-alkylation of secondary alcohols with primary alcohols is accomplished by a hydrogen autotransfer process catalyzed by RUCl2(DMSO)(4). The reaction can produce either simple alkylated secondary alcohols or alpha,beta-unsaturated ketones with good to excellent results just by choosing the appropriate starting secondary alcohol (methyl or longer chain secondary alcohol, respectively), as well as quinolines (by using 2-aminobenzyl alcohol). (c) 2006 Elsevier Ltd. All rights reserved.
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收藏
页码：8982 / 8987
页数：6
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