Reducing implant-related infections: active release strategies

被引:959
作者
Hetrick, Evan M. [1 ]
Schoenfisch, Mark H. [1 ]
机构
[1] Univ N Carolina, Dept Chem, Chapel Hill, NC 27599 USA
关键词
D O I
10.1039/b515219b
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Despite sterilization and aseptic procedures, bacterial infection remains a major impediment to the utility of medical implants including catheters, artificial prosthetics, and subcutaneous sensors. Indwelling devices are responsible for over half of all nosocomial infections, with an estimate of 1 million cases per year (2004) in the United States alone. Device-associated infections are the result of bacterial adhesion and subsequent biofilm formation at the implantation site. Although useful for relieving associated systemic infections, conventional antibiotic therapies remain ineffective against biofilms. Unfortunately, the lack of a suitable treatment often leaves extraction of the contaminated device as the only viable option for eliminating the biofilm. Much research has focused on developing polymers that resist bacterial adhesion for use as medical device coatings. This tutorial review focuses on coatings that release antimicrobial agents (i.e., active release strategies) for reducing the incidence of implant-associated infection. Following a brief introduction to bacteria, biofilms, and infection, the development and study of coatings that slowly release antimicrobial agents such as antibiotics, silver ions, antibodies, and nitric oxide are covered. The success and limitations of these strategies are highlighted.
引用
收藏
页码:780 / 789
页数:10
相关论文
共 52 条
[41]   Polyclonal human antibodies reduce bacterial attachment to soft contact lens and corneal cell surfaces [J].
Rediske, AM ;
Koenig, AL ;
Barekzi, N ;
Ameen, LC ;
Slunt, JB ;
Grainger, DW .
BIOMATERIALS, 2002, 23 (23) :4565-4572
[42]   Polyurethane coatings release bioactive antibodies to reduce bacterial adhesion [J].
Rojas, IA ;
Slunt, JB ;
Grainger, DW .
JOURNAL OF CONTROLLED RELEASE, 2000, 63 (1-2) :175-189
[43]   Antimicrobial efficacy of a new antibiotic-loaded poly(hydroxybutyric-co-hydroxyvaleric acid) controlled release system [J].
Rossi, S ;
Azghani, AO ;
Omri, A .
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2004, 54 (06) :1013-1018
[44]  
RUBBO H, 1994, J BIOL CHEM, V269, P26066
[45]   Controlled release of antibiotics from biomedical polyurethanes: Morphological and structural features [J].
Schierholz, JM ;
Steinhauser, H ;
Rump, AFE ;
Berkels, R ;
Pulverer, G .
BIOMATERIALS, 1997, 18 (12) :839-844
[46]   Improving the thromboresistivity of chemical sensors via nitric oxide release: Fabrication and in vivo evaluation of NO-releasing oxygen-sensing catheters [J].
Schoenfisch, MH ;
Mowery, KA ;
Rader, MV ;
Baliga, N ;
Wahr, JA ;
Meyerhoff, ME .
ANALYTICAL CHEMISTRY, 2000, 72 (06) :1119-1126
[47]   Adhesion of Staphylococcus to orthopaedic metals, an in vivo study [J].
Sheehan, E ;
McKenna, J ;
Mulhall, KJ ;
Marks, P ;
McCormack, D .
JOURNAL OF ORTHOPAEDIC RESEARCH, 2004, 22 (01) :39-43
[48]   Biofilms and antibiotic therapy: Is there a role for combating bacterial resistance by the use of novel drug delivery systems? [J].
Smith, AW .
ADVANCED DRUG DELIVERY REVIEWS, 2005, 57 (10) :1539-1550
[49]   Incorporation of different antibiotics into carbonated hydroxyapatite coatings on titanium implants, release and antibiotic efficacy [J].
Stigter, M ;
Bezemer, J ;
de Groot, K ;
Layrolle, P .
JOURNAL OF CONTROLLED RELEASE, 2004, 99 (01) :127-137
[50]  
Vacheethasanee K., 2000, HDB BACTERIAL ADHESI, P73, DOI DOI 10.1007/978-1-59259-224-1_5