Significantly improved method for the Pd-catalyzed coupling of phenols with aryl halides: Understanding ligand effects

被引：295

作者：

Burgos, Carlos H. ^{[1
]}

Barder, Timothy E. ^{[1
]}

Huang, Xiaohua ^{[1
]}

Buchwald, Stephen L. ^{[1
]}

机构：

[1] MIT, Dept Chem, Cambridge, MA 02139 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 26期

关键词：

biaryl phosphines; C-O bond formation; palladium; substituent effects; synthetic methods;

D O I：

10.1002/anie.200601253

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) A variety of diaryl ethers were synthesized by the Pd-catalyzed reaction of (hetero)-aryl halides and phenols. These reactions were achieved through the use of two new di-tert-butylphosphino biaryl ligands that overcome several limitations of previously described methods. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：4321 / 4326

页数：6

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