Oxidative amide synthesis and N-terminal α-amino group ligation of peptides in aqueous medium

被引：167

作者：

Chan, Wing-Kei

Ho, Chi-Ming

Wong, Man-Kin

Che, Chi-Ming

机构：

[1] Univ Hong Kong, Dept Chem, Inst Mol Technol Drug Discovery & Synth, Hong Kong, Hong Kong, Peoples R China

[2] Univ Hong Kong, Open Lab Chem Biol, Inst Mol Technol Drug Discovery & Synth, Hong Kong, Hong Kong, Peoples R China

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2006年 / 128卷 / 46期

关键词：

D O I：

10.1021/ja064479s

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new method for oxidative synthesis of amides from alkynes and amines in high yields (up to 96%) using [Mn(2,6-Cl2TPP)Cl] 1 as a catalyst and Oxone/H2O2 as an oxidant in aqueous medium has been developed. This method could be used for N-terminal α-amino group ligation of unprotected peptides with aryl, aliphatic, and internal alkynes under mild conditions. Copyright © 2006 American Chemical Society.

引用

页码：14796 / 14797

页数：2

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