Effects of the nitric oxide synthase inhibitor N-omega nitro-L-arginine methyl ester on electrical activity and ion channels of mouse pancreatic B cells

被引:19
作者
KrippeitDrews, P
Welker, S
Drews, G
机构
[1] UNIV TUBINGEN,INST PHARM,D-72076 TUBINGEN,GERMANY
[2] UNIV TUBINGEN,INST PHYSIOL,D-72076 TUBINGEN,GERMANY
关键词
D O I
10.1006/bbrc.1996.1007
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The effects of the nitric oxide (NO) synthase inhibitor N-omega-nitro-L-arginine methyl ester (L-NAME) were studied on electrical activity, K-ATP(+) currents and voltage-dependent K+ and Ca2+ channel currents in mouse pancreatic B cells. In the presence of 15 mM glucose, L-NAME (>5 mM) depolarized the B cell membrane and electrical activity became continuous. The depolarization caused by L-NAME was not reversed by the addition of a membrane permeant cyclic GMP analogue. L-NAME inhibited the whole-cell K-ATP(+) current reversibly by reducing the single channel current conductance and open probability. The results are consistent with the assumption that L-NAME depolarizes the B cell membrane by a direct action on the K-ATP(+) channel. L-NAME also influenced the whole-cell current through voltage-dependent K+ and Ca2+ channels. (C) 1996 Academic Press, Inc.
引用
收藏
页码:199 / 205
页数:7
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