Hypothesis: RNA editing of microRNA target sites in humans?

被引:69
作者
Liang, Han
Landweber, Laura F.
机构
[1] Princeton Univ, Dept Chem, Princeton, NJ 08544 USA
[2] Princeton Univ, Dept Ecol & Evolutionary Biol, Princeton, NJ 08544 USA
关键词
A-to-I RNA editing; microRNA repression; microRNA target sites; tissue specificity;
D O I
10.1261/rna.296407
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Adenosine (A) to inosine (I) RNA editing occurs widely in the human transcriptome, and a large proportion of editing sites are within untranslated regions (UTRs). MicroRNAs (miRNAs), an abundant class of regulatory genes, specify the expression of a large number of target genes by pairing to their 39 UTRs. To study the interplay between these two post-transcriptional events, we developed a computational pipeline to integrate sequence and miRNA tissue specificity data. The results show that some A-to-I RNA editing positions have a potential to block the miRNA: target recognition, although further computational simulation suggests that RNA editing tends to avoid miRNA target sites in general. We propose that a small proportion of RNA editing events may provide an additional layer of control on miRNA-mediated repression. Further investigation is needed to elucidate the functional effect of these special RNA editing events.
引用
收藏
页码:463 / 467
页数:5
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