Synthesis, Structure, and Antifungal Activity of Dihydropyridones Containing Boronate Esters

被引：9

作者：

Appoh, Francis E. ^{[1
]}

Wheaton, Susan L. ^{[1
]}

Vogels, Christopher M. ^{[1
]}

Baerlocher, Felix J. ^{[2
]}

Decken, Andreas ^{[3
]}

Westcott, Stephen A. ^{[1
]}

机构：

[1] Mt Allison Univ, Dept Chem, Sackville, NB E4L 1G8, Canada

[2] Mt Allison Univ, Dept Biol, Sackville, NB E4L 1G7, Canada

[3] Univ New Brunswick, Dept Chem, Fredericton, NB E3B 5A3, Canada

来源：

HETEROATOM CHEMISTRY | 2009年 / 20卷 / 01期

关键词：

DIELS-ALDER REACTION; MOLECULAR-STRUCTURES; ACID; COMPLEXES; INHIBITORS; CATALYSTS; IMINES; MILD;

D O I：

10.1002/hc.20512

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We have prepared a series of novel 2,3-dihydro-4-pyridones containing boronate esters using the aza Diels-Alder reaction with Danishefsky's diene and imines derived from formylphenylboronic acids. This reaction can be carried out in moderate to high yields using Yb(OTf)(3) as a Lewis acid catalyst. Two new boron compounds exhibited moderate antifungal activity (at 100 mu g disk(-1)) using Amphotericin B as a control. (C) 2009 Wiley Periodicals, Inc. Heteroatom Chem 20:56-63, 2009; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.20512

引用

页码：56 / 63

页数：8

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