Shared components of mitochondrial and peroxisomal division

被引:102
作者
Schrader, Michael [1 ]
机构
[1] Univ Marburg, Dept Cell Biol & Cell Pathol, D-35037 Marburg, Germany
来源
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH | 2006年 / 1763卷 / 5-6期
关键词
dynamin; fission; Fis1; mitochondria; peroxisome; Pex11;
D O I
10.1016/j.bbamcr.2006.01.004
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Mitochondria and peroxisomes are ubiquitous subcellular organelles, which are highly dynamic and display large plasticity. Recent studies have led to the surprising finding that both organelles share components of their division machinery, namely the dynamin-related protein DLP1/Drp1 and hFis1, which recruits DLP1/Drp1 to the organelle membranes. This review addresses the current state of knowledge concerning the dynamics and fission of peroxisomes, especially in relation to mitochondrial morphology and division in mammalian cells. (c) 2006 Elsevier B.V. All rights reserved.
引用
收藏
页码:531 / 541
页数:11
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