Endocytosis and cancer

被引：92

作者：

Polo, S

Pece, S

Di Fiore, PP

机构：

[1] IFOM, I-20139 Milan, Italy

[2] Ist Europeo Oncol, I-20141 Milan, Italy

[3] Univ Milan, Sch Med, I-20122 Milan, Italy

来源：

CURRENT OPINION IN CELL BIOLOGY | 2004年 / 16卷 / 02期

关键词：

D O I：

10.1016/j.ceb.2004.02.003

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Eukaryotic cells use endocytosis to internalise plasma membrane, surface receptors and their ligands, viruses and various extracellular soluble molecules. Endocytosis has been regarded as a long-term mechanism of signal attenuation via receptor clearance from the cell surface. However, additional, and quite unexpected, functions for endocytosis have emerged, which, together with its attenuation function, project a central role for this process in cellular homeostasis and control of proliferation. Subversion of endocytic control is thus predicted to play a causative role in hyperproliferative conditions, first and foremost cancer.

引用

收藏

页码：156 / 161

页数：6

相关论文

共 51 条

[1] Ubiquitin: not just for proteasomes anymore [J].

Aguilar, RC ;

Wendland, B .

CURRENT OPINION IN CELL BIOLOGY, 2003, 15 (02) :184-190

[2] Prospective identification of tumorigenic breast cancer cells [J].

Al-Hajj, M ;

Wicha, MS ;

Benito-Hernandez, A ;

Morrison, SJ ;

Clarke, MF .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (07) :3983-3988

[3] Notch signaling: Cell fate control and signal integration in development [J].

Artavanis-Tsakonas, S ;

Rand, MD ;

Lake, RJ .

SCIENCE, 1999, 284 (5415) :770-776

[4] Src promotes destruction of c-Cbl: Implications for oncogenic synergy between Src and growth factor receptors [J].

Bao, J ;

Gur, G ;

Yarden, Y .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (05) :2438-2443

[5] LOSS OF EPITHELIAL DIFFERENTIATION AND GAIN OF INVASIVENESS CORRELATES WITH TYROSINE PHOSPHORYLATION OF THE E-CADHERIN BETA-CATENIN COMPLEX IN CELLS TRANSFORMED WITH A TEMPERATURE-SENSITIVE V-SRC GENE [J].

BEHRENS, J ;

VAKAET, L ;

FRIIS, R ;

WINTERHAGER, E ;

VANROY, F ;

MAREEL, MM ;

BIRCHMEIER, W .

JOURNAL OF CELL BIOLOGY, 1993, 120 (03) :757-766

[6] The endocytic protein α-adaptin is required for numb-mediated asymmetric cell division in Drosophila [J].

Berdnik, D ;

Török, T ;

González-Gaitán, M ;

Knoblich, JA .

DEVELOPMENTAL CELL, 2002, 3 (02) :221-231

[7] Caveolae: Mining little caves for new cancer targets [J].

Carver, LA ;

Schnitzer, JE .

NATURE REVIEWS CANCER, 2003, 3 (08) :571-581

[8] Split personalities: the agonistic antagonist Sprouty [J].

Christofori, G .

NATURE CELL BIOLOGY, 2003, 5 (05) :377-379

[9] Regulated portals of entry into the cell [J].

Conner, SD ;

Schmid, SL .

NATURE, 2003, 422 (6927) :37-44

[10] When ubiquitin meets ubiquitin receptors: a signalling connection [J].

Di Fiore, PP ;

Polo, S ;

Hofmann, K .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2003, 4 (06) :491-497

← 1 2 3 4 5 6 →