Establishment of Broadly Applicable Reaction Conditions for the Palladium-Catalyzed Direct Arylation of Heteroatom-Containing Aromatic Compounds

被引：544

作者：

Liegault, Benoit ^{[1
]}

Lapointe, David ^{[1
]}

Caron, Laurence ^{[1
]}

Vlassova, Anna ^{[1
]}

Fagnou, Keith ^{[1
]}

机构：

[1] Univ Ottawa, Ctr Catalysis Res & Innovat, Dept Chem, Ottawa, ON K1N 6N5, Canada

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2009年 / 74卷 / 05期

基金：

加拿大自然科学与工程研究理事会;

关键词：

C-H ARYLATION; CROSS-COUPLING REACTIONS; DIRECT C-2 ARYLATION; PROTON-ABSTRACTION MECHANISM; ARYL BOND FORMATION; PHOSPHINE-FREE; INTRAMOLECULAR ARYLATION; REGIOSELECTIVE SYNTHESIS; FREE (NH)-INDOLES; EFFICIENT ACCESS;

D O I：

10.1021/jo8026565

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Conditions for the palladium-catalyzed direct arylation of a wide range of heterocycles with aryl bromides are reported. Those conditions employ a stoichiometric ratio of both coupling partners, as well as a substoichiometric quantity of pivalic acid, which results in significantly faster reactions. An evaluation of the influence of the nature of the aryl halide has also been carried out.

引用

页码：1826 / 1834

页数：9

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