Manaarenolides A-I, diterpenoids from the soft coral Sinularia manaarensis

被引：70

作者：

Su, Jui-Hsin

Ahmed, Atallah F.

Sung, Ping-Jyun

Chao, Chih-Hua

Kuo, Yao-Haur

Sheu, Jyh-Horng ^{[1
]}

机构：

[1] Natl Sun Yat Sen Univ, Dept Marine Biotechnol & Resources, Kaohsiung 804, Taiwan

[2] Mansoura Univ, Fac Pharm, Dept Pharmacognosy, Mansoura 35516, Egypt

[3] Natl Museum Marine Biol & Aquarium, Pingtung 944, Peoples R China

[4] Natl Res Inst Chinese Med, Taipei 112, Taiwan

来源：

JOURNAL OF NATURAL PRODUCTS | 2006年 / 69卷 / 08期

关键词：

D O I：

10.1021/np050483q

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Nine cembrane-type diterpenoids, manaarenolides A-I(1-9), along with two known cembranolides, 10 and 11, have been isolated from the ethyl acetate extract of the Taiwanese soft coral Sinularia manaarensis. Among these metabolites, diterpenes ( 1, 2, 5, and 6) were discovered for the first time as the hydroperoxycembranolides possessing a delta-lactone ring. The 13-epimeric metabolites 7 and 8 have been shown to exhibit moderate cytotoxic activity against Hepa59T/ VGH, KB, Hela, and Med cancer cell lines. The biosynthetic relationship between these new metabolites and 10 and 11 is also discussed.

引用

页码：1134 / 1139

页数：6

共 24 条

[1] Oxygenated terpenoids from a Formosan soft coral Sinularia gibberosa [J].