An alternate enantiospecific synthesis of methyl (S)-7-tert-butoxycarbonyl-2,3,4,5-tetrahydro-4-methyl-3-oxo-1H-1,4-benzodiazepine-2-acetate

被引:18
作者
Ku, TW
Ali, FE
Bondinell, WE
Erhard, KF
Huffman, WF
Venslavsky, JW
Yuan, CCK
机构
[1] Department of Medicinal Chemistry, Research and Development Division, SmithKline Bescham Pharmaceuticals, King of Prussia, PA 19406-0939
关键词
D O I
10.1016/S0040-4039(97)00570-4
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
An alternate enantiospecific synthesis of methyl (S)-7-tert-butoxycarbonyl-2,3,4,5-tetrahydro-4-methyl-3-oxo-1H-1,4-benzodiazepine-2-acetate (5) is reported. The key step, which involves an intermolecular displacement of the activated aryl fluoride (9) by L-aspartic acid beta-methyl ester, proceeds without racemization. (C) 1997 Elsevier Science Ltd.
引用
收藏
页码:3131 / 3134
页数:4
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