An alternate enantiospecific synthesis of methyl (S)-7-tert-butoxycarbonyl-2,3,4,5-tetrahydro-4-methyl-3-oxo-1H-1,4-benzodiazepine-2-acetate

被引：18

作者：

Ku, TW

Ali, FE

Bondinell, WE

Erhard, KF

Huffman, WF

Venslavsky, JW

Yuan, CCK

机构：

[1] Department of Medicinal Chemistry, Research and Development Division, SmithKline Bescham Pharmaceuticals, King of Prussia, PA 19406-0939

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 18期

关键词：

D O I：

10.1016/S0040-4039(97)00570-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An alternate enantiospecific synthesis of methyl (S)-7-tert-butoxycarbonyl-2,3,4,5-tetrahydro-4-methyl-3-oxo-1H-1,4-benzodiazepine-2-acetate (5) is reported. The key step, which involves an intermolecular displacement of the activated aryl fluoride (9) by L-aspartic acid beta-methyl ester, proceeds without racemization. (C) 1997 Elsevier Science Ltd.

引用

页码：3131 / 3134

页数：4

共 18 条

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