HIV co-receptor inhibitors as novel class of anti-HIV drugs

被引：31

作者：

Schols, Dominique ^{[1
]}

机构：

[1] Katholieke Univ Leuven, Rega Inst Med Res, B-3000 Louvain, Belgium

来源：

ANTIVIRAL RESEARCH | 2006年 / 71卷 / 2-3期

关键词：

CCR5; CXCR4; antagonist; HIV; chemokine receptor; gp120; envelope; HUMAN-IMMUNODEFICIENCY-VIRUS; CHEMOKINE RECEPTOR CXCR4; SMALL-MOLECULE INHIBITOR; HUMAN LYMPHOID-TISSUE; INFECTION IN-VITRO; TYPE-1; REPLICATION; CCR5; ANTAGONIST; HIGHLY POTENT; TROPIC HIV-1; SELECTIVE-INHIBITION;

D O I：

10.1016/j.antiviral.2006.04.009

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Entry inhibitors constitute a new class of drugs to treat infection by human immunodeficiency virus type 1 (HIV-1). The first member of this class, enfuvirtide, previously known as T-20 and targeting gp41, has now been licensed for therapeutic use. Several other entry inhibitors are in various stages of pre-clinical or clinical development. In this review we focus on the chemokine receptor inhibitors targeting CCR5 and CXCR4 that are the main HIV co-receptors for viral entry. (c) 2006 Elsevier B.V. All rights reserved.

引用

页码：216 / 226

页数：11

共 97 条

[11] SYNTHESIS AND STRUCTURE-ACTIVITY-RELATIONSHIPS OF PHENYLENEBIS(METHYLENE)-LINKED BIS-TETRAAZAMACROCYCLES THAT INHIBIT HIV REPLICATION - EFFECTS OF MACROCYCLIC RING SIZE AND SUBSTITUENTS ON THE AROMATIC LINKER [J].

BRIDGER, GJ ;

SKERLJ, RT ;

THORNTON, D ;

PADMANABHAN, S ;

MARTELLUCCI, SA ;

HENSON, GW ;

ABRAMS, MJ ;

YAMAMOTO, N ;

DEVREESE, K ;

PAUWELS, R ;

DECLERCQ, E .

JOURNAL OF MEDICINAL CHEMISTRY, 1995, 38 (02) :366-378

[12] Enfuvirtide [J].

Chen, RY ;

Kilby, JM ;

Saag, MS .

EXPERT OPINION ON INVESTIGATIONAL DRUGS, 2002, 11 (12) :1837-1843

[13] The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates [J].

Choe, H ;

Farzan, M ;

Sun, Y ;

Sullivan, N ;

Rollins, B ;

Ponath, PD ;

Wu, LJ ;

Mackay, CR ;

LaRosa, G ;

Newman, W ;

Gerard, N ;

Gerard, C ;

Sodroski, J .

CELL, 1996, 85 (07) :1135-1148

[14] IDENTIFICATION OF RANTES, MIP-1-ALPHA, AND MIP-1-BETA AS THE MAJOR HIV-SUPPRESSIVE FACTORS PRODUCED BY CD8(+) T-CELLS [J].

COCCHI, F ;

DEVICO, AL ;

GARZINODEMO, A ;

ARYA, SK ;

GALLO, RC ;

LUSSO, P .

SCIENCE, 1995, 270 (5243) :1811-1815

[15] The V3 domain of the HIV-1 gp120 envelope glycoprotein is critical for chemokine-mediated blockade of infection [J].

Cocchi, F ;

DeVico, AL ;

GarzinoDemo, A ;

Cara, A ;

Gallo, RC ;

Lusso, P .

NATURE MEDICINE, 1996, 2 (11) :1244-1247

[16] Change in coreceptor use correlates with disease progression in HIV-1-infected individuals [J].

Connor, RI ;

Sheridan, KE ;

Ceradini, D ;

Choe, S ;

Landau, NR .

JOURNAL OF EXPERIMENTAL MEDICINE, 1997, 185 (04) :621-628

[17]

Daelemans D, 2000, MOL PHARMACOL, V57, P116

[18] HIGHLY POTENT AND SELECTIVE-INHIBITION OF HUMAN-IMMUNODEFICIENCY-VIRUS BY THE BICYCLAM DERIVATIVE JM3100 [J].

DE CLERCQ, E ;

YAMAMOTO, N ;

PAUWELS, R ;

BALZARINI, J ;

WITVROUW, M ;

DEVREESE, K ;

DEBYSER, Z ;

ROSENWIRTH, B ;

PEICHL, P ;

DATEMA, R ;

THORNTON, D ;

SKERLJ, R ;

GAUL, F ;

PADMANABHAN, S ;

BRIDGER, G ;

HENSON, G ;

ABRAMS, M .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1994, 38 (04) :668-674

[19] Genetic restriction of HIV-1 infection and progression to AIDS by a deletion allele of the CKR5 structural gene [J].

Dean, M ;

Carrington, M ;

Winkler, C ;

Huttley, GA ;

Smith, MW ;

Allikmets, R ;

Goedert, JJ ;

Buchbinder, SP ;

Vittinghoff, E ;

Gomperts, E ;

Donfield, S ;

Vlahov, D ;

Kaslow, R ;

Saah, A ;

Rinaldo, C ;

Detels, R ;

OBrien, SJ .

SCIENCE, 1996, 273 (5283) :1856-1862

[20] POTENT AND SELECTIVE-INHIBITION OF HUMAN-IMMUNODEFICIENCY-VIRUS (HIV)-1 AND HIV-2 REPLICATION BY A CLASS OF BICYCLAMS INTERACTING WITH A VIRAL UNCOATING EVENT [J].

DECLERCO, E ;

YAMAMOTO, N ;

PAUWELS, R ;

BABA, M ;

SCHOLS, D ;

NAKASHIMA, H ;

BALZARINI, J ;

DEBYSER, Z ;

MURRER, BA ;

SCHWARTZ, D ;

THORNTON, D ;

BRIDGER, G ;

FRICKER, S ;

HENSON, G ;

ABRAMS, M ;

PICKER, D .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (12) :5286-5290

← 1 2 3 4 5 6 7 8 9 10 →