Age related changes in essential fatty acid metabolism in cultured rat heart myocytes

被引：9

作者：

Lorenzini, A ^{[1
]}

Bordoni, A ^{[1
]}

Spano, C ^{[1
]}

Turchetto, E ^{[1
]}

Biagi, PL ^{[1
]}

Hrelia, S ^{[1
]}

机构：

[1] UNIV BOLOGNA,DIPARTIMENTO BIOCHIM G MORUZZI,I-40126 BOLOGNA,ITALY

来源：

PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS | 1997年 / 57卷 / 02期

关键词：

D O I：

10.1016/S0952-3278(97)90004-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We previously demonstrated that cultured neonatal rat myocytes have the capacity to desaturate/elongate essential fatty acids, alpha-linolenic acid conversion being higher than linoleic acid conversion. The whole process of highly unsaturated fatty acid formation from linoleic and alpha-linolenic acids slows with aging. In this study we grew heart myocytes in culture for different periods of time, and we observed a decrease in the desaturating/elongating activities for both substrates as the cells aged in culture. Alpha-linolenic acid conversion into highly unsaturated fatty acids was less impaired by aging than linoleic acid conversion. These modifications are correlated to the age-dependent alterations observed in the total lipid fatty acid composition, which caused a decrease in the unsaturation index. Changes in the lipid composition that occur in aging cultures parallel those reported for several tissues upon aging in the whole animal. The data herein reported may suggest the possibility of counteracting the effects of aging on lipid metabolism by supplementing cultures with appropriate amounts of highly unsaturated fatty acids.

引用

页码：143 / 147

页数：5

共 21 条

[1] GAMMA-LINOLENIC ACID DIETARY SUPPLEMENTATION CAN REVERSE THE AGING INFLUENCE ON RAT-LIVER MICROSOME DELTA-6-DESATURASE ACTIVITY [J].